Improper Injection Site Not All Injection Sites Are Equal Choosing the wrong injection site can lead to discomfort, complications, or even ineffective absorption of Vitamin B12
Davin8r September 10, 2024, 3:22am #8 Neo: Any sense of this increased baseline insulin levels, thats my worry with GLP-1 as CR mimetic that key longevity pathway (and IGF, etc) might actually go in the wrong direction with these Fasting insulin went down dose-dependently in the retatrutide phase 2 study, for instance (see Table S6): I havent looked at sema or tirz data specifically, but Id imagine its the same
Study Design Type: Phase 2, double-blind, randomized, placebo-controlled study Participants: 338 adults (BMI 30 or BMI 27 with a coexisting condition) Groups: Retatrutide 1 mg, 4 mg, 8 mg, 12 mg (different initial doses 2 or 4 mg) and placebo Duration: 48 weeks (plus 4 weeks follow-up) Administration: subcutaneous, 1x weekly Primary endpoint: percentage change in body weight at week 24 Secondary endpoints: change in weight at week 48, 5%, 10%, 15% weight reduction
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