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More recent modelling (Miller et al ., 2011) has utilized the X-ray structure of the GLP-1R NTD (Underwood et al ., 2010) fused to 250 diverse helical bundle domain models from 25 transmembrane bundles, alongside experimentally derived photo-affinity contacts, in order to further understand the ligandreceptor interactions

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Importantly, M-type K + channel blockers increased input resistance by 21.1%2.1% (from 1.120.10 to 1.370.14 G, n =3) with a calculated E rev of 74.03.7 mV ( n =3), which suggested a closure of putative K + conductance