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Studies demonstrated that transplantation of this bacteria in diabetic models can improve treatment efficacy and diabetes complications [55]

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Their effects are wide-ranging, and adolescence is a critical window when those effects can be most significant

Notably, mutations in PROP1 (Prop1df/df, Ames dwarf mice) and POU1F1 (Pou1f1dw/dw, Snell dwarf mice) disrupt anterior pituitary development, leading to deficiencies in GH, thyroid-stimulating hormone (TSH), and prolactin (PRL), significantly extending lifespan ( Igf1r +/) show extended lifespan, particularly in females, while lit/lit mice, mutated in GHRH, also display longevity advantages

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