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Research published in Biochemical Pharmacology demonstrated that treating cells with 5-Amino-1MQ effectively blocks this leak. It inhibits NNMT, forcing Nicotinamide back into the salvage pathway

Stanley TL et al

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in diet-induced obese mice, 5-Amino-1-MQ significantly reduces total body weight, fat mass, and adipocyte size, while improving insulin sensitivity and glucose tolerance 2,3