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The mechanism remains unknown, and until it is identified, targeted prevention strategies cannot be developed

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Veenstra-VanderWeeleJMullerCLIwamotoHSauerJEOwensWAShahCRet al

Without DAC, the half-life drops to roughly 30 minutes

Although the renoprotective effects of SGLT-2 inhibitors are maintained at these eGFRs, the glucose-lowering effects of SGLT-2 inhibitors are significantly impaired at low eGFRs

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