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This connection between the gut & pancreatic islets may be responsible for ~50% of postprandial insulin release (Perley & Kipnis, J Clin Invest 46:1954-1962

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Semaglutide produces greater weight loss as monotherapy (15-17% vs 11.8%), but the two peptides can be combined for additive effects

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Molecular redundancy is when two or more effectors utilize the same molecular mechanism to act on or regulate the same target ( Target redundancy is when the target protein is modulated by two or more effectors, utilizing different mechanisms ( Pathway redundancy is when effectors have different targets, but these targets are part of a single pathway that regulates the same overall process ( Cellular process redundancy is when effectors regulate redundant or complementary pathways that together control a cellular process