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However, when hyperhomocysteinemia was simulated and a cysteine-block applied (Figure 6B), it prevented a significant elevation in cytosolic GSH levels: GSH levels deviate by only about 10% from the steady-state at nominal values of and

The study was performed in accordance with the Helsinki Declaration and approved by the ethics committee of Musashino Red Cross Hospital

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However, the efficiency of the ATP supply or utilization for GSH production seems to be very low because only 0.5 % of the total ATP regenerated in the glycolytic pathway is used for GSH production under anaerobic conditions [13]

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To standardize this tracking, patients can utilize validated medical questionnaires