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Low Se status has been associated with impaired immune function with cognitive decline and increased risk of death, while Se supplementation with deficient individuals reduces the risk of prostate cancer, lung cancer, colorectal cancer, and bladder [76, 77]

Ethics declarations Competing Interests Jan Cendelin is a member of the editorial board of The Cerebellum

The medication increases by 2.5 mg every four weeks, and it can take 16 to 20 weeks to reach the higher therapeutic doses of 10 mg or 15 mg

Moreover, in patients with calcification associated with rheumatoid arthritis, the circulating osteogenic endothelial progenitor cells (EPC) are related to vascular aging, encountering a decline in both number and differentiation potential, culminating in hastened cellular senescence (89, 90)

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