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Key Innovation: The addition of a C18 fatty diacid side chain extends its half-life to approximately 7 days, enabling once-weekly dosing similar to modern GLP-1 receptor agonists

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Interventions aimed at blocking collagen and hyaluronan production, such as a neutralizing antibody against TGF- [127], the angiotensin inhibitor losartan [128,129,130,131], or the antifibrotic drugs tranilast and pirfenidone [132,133,134] have shown promising results in alleviating solid stress and increasing breast tumor blood supply and drug delivery