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However, regardless of the specifics of the study design, participants safety should always be an utmost priority when conducting an FIH trial

Patients diagnosed as having COVID-19 were more likely to die of a non-CV cause than a CV cause (74.5% vs 25.5%), while the relationship was the inverse in patients without COVID-19 (32.5% non-CV vs 67.5% CV deaths)

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They are easy to take, well-studied, and have a solid safety record at doses up to 500 mg per day

The blood pressure targets should be individualised and account for possible adverse outcomes, such as postural hypotension, which is particularly relevant in people with concurrent autonomic neuropathy