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How to Manage Plateaus Safely A weight loss plateau is a normal part of the process

Tirzepatide (Zepbound) is another medication that functions as a GLP1-RA, but also as a gastric inhibitory peptide (GIP) agonist

[3] It is important to note that retatrutide has not received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA) (MHRA medicines licensing database, accessed 2025

These can take months to subside, and for those who suffer longer-term, many end up withdrawing their use

Women taking tirzepatide who use oral contraceptives should be advised that delayed gastric emptying may reduce contraceptive efficacy

Patients may experience severe nausea, dizziness, tachycardia, or mood instability