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However: Many lack strong human clinical trials

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The combination has a low risk of hypoglycaemia when used without sulfonylureas or insulin, though gastrointestinal side effects are common initially and usually improve with time

Acta Pharmacol Sin 33(1):7581 Heuvelman VD Van Raalte DH, Smits MM (2020) Cardiovascular effects of glucagon-like peptide 1 receptor agonists: from mechanistic studies in humans to clinical outcomes