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doi: 10.1021/mp700113r 51

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Some people are super-responders and achieve great results with very low doses known as micro-doses, while others may need to titrate up to the highest dose to get the desired effect, said Isaacs

Phosphodiesterase-5 (PDE5) inhibitors such as sildenafil are often effective first-line treatments and are generally safe to use alongside GLP-1 medications, though they are contraindicated with nitrate medications and riociguat, and should be used with caution in unstable cardiovascular disease or if taking alpha-blockers