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In apolipoprotein E knockout (ApoE - / - ) mouse models, it significantly reduces the area of atherosclerotic plaques and the formation of lipid necrotic cores, concurrently decreasing serum inflammatory factors (e.g., interleukin6, tumor necrosis factor) [368]

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Additionally, in vivo experiments should be conducted to assess the drugs safety, efficacy, long-term effects, and potential side effects

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