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While GIP contributes to tirzepatides efficacy, its effects on the gut may compound GLP-1s already substantial impact on gastric motility and digestive function

Reductions of glycemic index and hyperinsulinemia by GLP-1 GLP-1 exerts an important effect directly on the brain, and this effect is probably even more important for the analogues than for the endogenous GLP-1 released after ingestion of protein and fat