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We therefore proposed to make the following two-stage methodologic updates to 412.190(a)(2) and adding a new paragraph (a)(3))

Almusafri F, Elamin HE, Khalaf TE, Ali A, Ben-Omran T, El-Hattab AW

Kamath BS, Srikanta BM, Dharmesh SM, Sarada R, Ravishankar GA (2008) Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis

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Drink at least 2.53 liters of water daily, and consider adding an electrolyte-balanced beverage (coconut water, sports drinks with 3:1 potassium-to-sodium ratio, or zero-sugar electrolyte tablets) to replace minerals lost through reduced eating and increased metabolism

All ultrasound images were recorded on S-VHS videotape for subsequent blinded analysis