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In conclusion, the pathological features and pathogenic factors of PD include the excessive accumulation of -Syn in the substantia nigra pars compacta or its gene mutation

Supplementary material The Supplementary Material for this article can be found online at: References 1 AdachiS.KawamotoT.OtsukaM.TodorokiT.FukaoK

doi: 10.1016/j.autrev.2020.102736 132 ZhangJRoschkeVBakerKPWangZAlarcnGSFesslerBJet al

This is particularly problematic in people with inadequate selenium intake and consequent low selenium levels

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