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In the tiny human trials so far it is well tolerated, but the sample sizes are small and selective (this isnt a good representation of either a)

After the surgery the animals were maintained under a 12 hour light/12 hour dark cycle and were closely monitored and gently handled for 5 minutes per day, 5-6 days after the surgery was performed [2]

All in all, it has suggested that how often the injections are administered and the amount that is administered depends on the aims and the individual