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Item 4 (whether a comprehensive literature search strategy was used) was also frequently rated as partially met, as most meta-analyses did not clarify whether grey literature was searched when appropriate or whether experts in the field were consulted

Typically, about 75 percent of weight loss comes from fat, with roughly 25 percent coming from fat-free mass, says Sriram Machineni, MD, an endocrinology, diabetes, and metabolism expert at Montefiore Health System in New York City

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