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Tuy nhin, c mt s trng hp ngi dng b nng trong ngi, ni mn hoc to bn sau khi s dng collagen, v y ch yu l do nhng nguyn nhn sau: Qu lm dng collagen: ung qu nhiu collagen ngoi kh nng hp th ca c th c th gy ra cc phn ng nh ni mn, to bn v cm gic nng trong ngi