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M1 macrophages are mainly activated by the innate immune system and are responsible for amplifying inflammatory reactions, while M2 macrophages are associated with the resolution of inflammation and tissue healing (Yang et al., 2022)
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Melanin is produced by melanocytes and transferred to these cells as they form meaning any shift in the type or amount of melanin being produced only becomes visible once the newly-formed cells reach the surface and the older, differently-pigmented cells have shed away
Blue circles represent values of individual studies where the circle size is proportional to the study weight in the random-effects model
RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
