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In this type, NPs are not the direct cause of oxidative stress

PDH: pyruvate dehydrogenase

Cells were exposed to different concentrations of SeChry@PURE G4 -LA 24 (25400 M of SeChry) and TMZ@PURE G4 -LA 24 (501000 M of TMZ)

Drmic et al., 2017) and severe muscle weakness (Klicek et al., 2013

Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]

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