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Like the approach used for the discovery cohort, we next searched for additional proteins that may be indicative of differences in the same cohort using (s)PLS-DA analysis

Researchers started every participant at the same base dose regardless of their target maintenance level, then increased the dose every four weeks until reaching the assigned tier

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Large-scale clinical studies in humans are still required to confirm their safety, efficacy, and potential therapeutic value

BMJ 372 , m4743 (2021)