DAO is an enzyme found in the gut that metabolizes histamine in the GI tract, which can be a significant source of histamine, especially in the presence of SIBO, candida overgrowth and certain pathogenic infections like Kl and ebsiella spp
For instance, semaglutide treatment is now used both for diabetes management and as an obesity treatment
However, despite the high frequency of sleep disturbances during AD course, there is an obvious lack of data that specifically discusses the molecular basis of AD-sleep disorders, apart from other AD-disruptions
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Some people have even needed to be hospitalized
Source : Vaziri-Harami R, Delkash P