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Some studies didnt register prior to their start, and there were some risks at the reporting bias

[DOI] [PMC free article] [PubMed] [Google Scholar] 132.Corona J.C., Duchen M.R

While hot flashes and mood swings get most of the attention, one lesser-known but equally frustrating issue is perimenopause itching

Nitric oxide, in turn, is known to modulate cytochrome c oxidase activity and mitochondrial oxygen consumption in a reversible manner, providing a plausible route by which endogenous morphine could restrain excessive energy flux, limit reactive oxygen species generation, and preserve organellar integrity under stress [13-15]

Glutathione helps neutralize these free radicals, promoting healthy cell function and skin regeneration

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain