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Common side effects include nausea, vomiting, constipation, and reduced appetitemost mild and temporary during dose escalation

[10] [11] This typically includes assessment of glycaemic control, cardiovascular risk factors, and treatment tolerability

accidental freezing), which may produce visible particles

and systemic and glucose-lowering effects

In contrast, bile acids conjugated with glycine or taurine exhibit increased amphiphilicity and solubility, rendering them membrane-impermeable and dependent on active transport to enter the brain [68,69]