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In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day (2-, 8-, and 22-fold the maximum recommended human dose [MRHD] of 2.4 mg/week, based on AUC) were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (0.6-, 2-, and 5-fold MRHD) were administered to the females

DPPH radicals are easily obtained by oxidation of hydrazines with lead dioxide, lead tetraacetate, potassium permanganate or silver oxide (Fig

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(Beijing, China) and ultraviolet spectrophotometry at a wavelength of 470 nm, in accordance with the manufacturers instructions