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Physical causes include nerve damage, hormonal issues, and medication side effects, particularly from certain antidepressants

Effects of vitamin B12 deficiency can result in a range of negative health effects

Standard topical application struggles to get peptides through the skin barrier

The liver stores substantial quantities of vitamin B12, and hepatocellular damagefrom conditions such as cirrhosis, hepatitis, or hepatocellular carcinomacan release these stores into the bloodstream

10.1016/j.intimp.2024.113645 190 WesterheideS