Natural GLP-1 is broken down within minutes by an enzyme called DPP-4
Yes, several GLP-1 medications are available, but they all carry facility-level prior authorizations to ensure they are prescribed according to strict safety and medical necessity criteria
These effects have nothing to do with b12

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Insulin resistance plays an important role in the pathophysiology of comorbid T2DM and depression and can be a trigger for dysregulation of insulin- and GLP-1-mediated signaling (both central and peripheral), neuroendocrine disorders (hypothalamicpituitaryadrenal system dysfunction and monoaminergic neurotransmission disorders), chronic low-intensity inflammation, oxidative stress, and disorders of the microbiota-gut-brain system, reducing the level of neurotrophic factors in the brain and changing synaptic plasticity
GRKs are believed to be important in -arrestin-biased signaling, because GRKs are able to promote high-affinity binding of -arrestin to GPCRs