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At the 2.4 mg + 2.4 mg maintenance dose, that is 4.8 mg total per week, so one vial covers 4 full weekly maintenance draws with about 0.8 mg total residual

CFTR modulator therapy with lumacaftor/ivacaftor alters plasma concentrations of lipid-soluble vitamins A and E in patients with cystic fibrosis

Xu, C., C.Y

The result: less intrinsic factor, less stomach acid, less surface area for absorption and a near-guaranteed B12 deficiency without lifelong supplementation

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