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Measurement using Mrx1-roGFP2 redox biosensor The Mrx1-roGFP2 ratio was determined during in vitro growth of Mtb strains in glycerol (0.2%) or propionate (10 mM and 20 mM) containing 7H9 medium as described in (Das et al, 2023)

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Intranasal delivery represents the most significant methodological advancement because it bypasses hepatic first-pass metabolism entirely, but technique sensitivity (nasal cavity anatomy, administration volume, head positioning post-dose) introduces reproducibility challenges that subcutaneous injection avoids

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It is a naturally occurring compound in the human body, and the concentrations used in serums are low

[4] These deficiencies often coexist, particularly in individuals with malabsorption conditions, vegetarian or vegan diets without supplementation, or chronic gastrointestinal disorders