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Document changes not just in A1C and weight but also patientreported changes in appetite, cravings, and lifestyle habits, including alcohol consumption

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Parkman HP, Van Natta ML, Abell TL et al (2013) Effect of nortriptyline on symptoms of idiopathic gastroparesis: the NORIG randomized clinical trial

These abnormalities appear to be driven by genetic and epigenetic factors modulated by stochastic events