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Paradoxically, however, reduced expression of specific mitophagy regulators, including PRKN [58] and BNIP3 [60], has been linked to worse prognosis in PDAC, underscoring the limitations of monogenic biomarkers in reflecting the functional state of mitophagy

Figure 1 This review summarizes current knowledge about NP, focusing on clinical conditions and probable causes, the relationship existing among oxidative stress, mitochondrial dysfunction and TRP channels activation and scientific evidence related to antioxidant supplementation

Shu et al., 2023)

Drugs@FDA, NDA 022505 (approved 10 Nov 2010)

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Research agrees with this as well