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The intervention resulted in positive changes in TC, LDL-C, VLDL-C, TAGs, aspartate aminotransferase (AST), alanine aminotransferase (ALT), insulin, hemoglobin A1c (HbA1c), total body fat percentage (TBF), waist and hip circumferences, visceral fat percentage, and systolic blood pressure (SBP)

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Additionally, patients with T2DM and comorbid cardiovascular or chronic kidney disease who received once-daily oral semaglutide (14 mg) exhibited a cardiovascular safety profile similar to that of the subcutaneous form [49]