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In this way, the synthesis of nitric oxide increases and the muscular tissues begin to receive a greater quantity of nutrients through the bloodstream

Vinik AI, Maser RE, Mitchell BD, et al

Once in the body, creatine is primarily taken up by muscle tissue, with approximately 1-2% per day non-enzymatically converting to creatinine, which is then excreted by the kidneys

Given the expression of St14 (matriptase) in the intestinal crypt cells, we next determined the role of matriptase-PAR2 signaling for postprandial GIP regulation by using PAR2-K36E mutant mice