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In the South Park: The End of Obesity teaser trailer, a doctor tells Cartman hes overweight and needs to start taking Semaglutide, an injection used to treat type 2 diabetes

Adults using semaglutide lost an average of 14.9% of their body weight over 68 weeks, compared to just 2.4% with placebo

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This includes the higher risk of heart disease and the reasons behind chest pain