Several analogs were later developed, including pioglitazone and troglitazone
If nausea increased after adding lipo C, the more likely explanation is coincidental dose escalation of tirzepatide during the same timeframe, or the cumulative effect of a larger weekly caloric deficit once both protocols are active
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Sources Endocrine Society Consuming more protein may protect patients taking an anti-obesity drug from muscle loss endocrine.org University of Utah Health Want to Lose Weight
This reflects the chronic and relapsing nature of obesity