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In addition, since L-theanine was shown to have a relaxing effect and gamma-aminobutyric acid (GABA) was an important inhibitory neurotransmitter, the mixture of L-theanine and GABA had a positive synergistic effect on sleep behavior, including sleep quality and duration in caffeine-induced awake rats, and the mechanism might be that the mixture could promote the expression of GABA receptor, which was conducive to sleep (38)

Therefore, published preclinical work reported preferential activation of the human AMY1 receptor, with substantially lower activation of AMY3 and the calcitonin receptor in the tested systems

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reported no grade 3 or higher toxicities

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Insulin sensitivity modulates IGF-1 receptor phosphorylation