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In the current study supraphysiological increases in circulating GLP1 offer a degree of protection against olanzapine-induced glucose tolerance and lipidemia, in parallel with a reduction in glucagon:insulin

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[1] In phase 3 trials, orforglipron produced 12.4% weight loss (27.3 lbs) at 72 weeks less than injectable tirzepatide (20%) but comparable to oral semaglutide

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doi:10.1111/j.1742-4658.2008.06743.x

One key challenge: tirzepatide is rapidly degraded by proteases in oral tissues, meaning even absorbed molecules may lose potency before reaching target receptors in the brain and pancreas