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Beyond cancer biology, DES(1-3) IGF-1 has been investigated in neuroprotection models, where its high potency and reduced IGFBP binding facilitate clean receptor activation in brain tissue preparations where IGFBP concentrations would otherwise limit native IGF-1 activity
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Liao et al., Enzymatic protection and biocompatibility screening of enzyme-loaded polymeric nanoparticles for neurotherapeutic applications
The current sate of knowledge has moved on in 30 odd years and yet B12 maintenance dose has since worsened

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