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These discoveries allowed to improve the design of TR-targeting drugs, in particular for TR1-selective thyromimetics, and a number of different ligands were subsequently developed: (3,5-dimethyl-4 (4-hydroxy-3- isopropylbenzyl)-phenoxy) acetic acid (GC-1) known as sobetirome, 3-[(3,5-dibromo-4-(4-hydroxy-3-(1-methylethyl)-phenoxy)-phenyl)-amino-3-oxopropanoic acid) known as eprotirome, KB2115, (3,5-dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy] methylphosphonic acid known as MB07344/VK2809, and 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile, also known as MGL-3196 and resmetirom

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