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Metformin is readily prescribed by GPs as first-line treatment for type 2 diabetes, whilst semaglutide for diabetes (Ozempic) can be prescribed when metformin alone provides insufficient control

However, GLP-1 medications arent standalone solutions

notably, it doesn't cause weight loss to the same degree but still offers significant benefits including improved glycemic control with low risk of hypoglycemia

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Interestingly, however, 6/32 cases (18%) of PanIN were GLP1R positive by immunohistochemistry (Table 1)

[1] [2] However, it is important to distinguish between direct causation and indirect risk factors