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They are often used alongside other tools like appetite suppressants, nutritional counseling, or meal replacements

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However, clinical studies have shown that treatment with leptin or its analogues does not significantly affect body weight, fat mass, glucose and insulin homeostasis, lipid profile, or food intake in individuals with obesity compared to placebo [76,77,78,79]

But it is best to start taking supplements a few months or more before conception, since it may take a few months to get their full benefits