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doi: 10.1089/met.2010.0025 57 IepsenEWTorekovSSHolstJJ
Data collected November and December 2025
Potential Side Effects While generally well-tolerated when properly dosed and monitored, Topiramate can cause side effects that range from mild to more serious
Contraindications:: Patients with a personal or family history of medullary thyroid carcinoma (based upon animal data - see FDA Warning) History of hypersensitivity to semaglutide or any of its excipients (serious reactions including angioedema & anaphylaxis have been reported) Side Effects: GI Adverse events: nausea, vomiting, constipation, diarrhea (~5-15%) most GI side side effects occur during dose initiation or escalation and wane after a few weeks (Drucker, 2024)
Counting by molecule type: 17 are peptides, 4 are small molecules (HM-15275, SP-2297, CS-120070, RAY-0221), 2 are Fc-fusion proteins (MWN-101, ZX2021), 1 is an ADC (IBI-3012), and 2 are listed as "chemical drugs" without more specificity (DYX116, XFL6)
Compounded semaglutide injections are $189/mo month-to-month, or from $149/mo on the 6-month plan, while tirzepatide begins at $289 monthly, with oral formulations available for patients who prefer tablets over injections
