Vomiting : Some clients may experience vomiting, particularly in the early stages of treatment
PubMed Nie Q, Li M, Huang C, et al
The colonic endocrine hormone PYY decreased following Satb2 deletion or during colonic mucosal injury The colonic mucosa harbors diverse enteroendocrine cells with indistinct morphologies, including enterochromaffin cells (producing 5-HT), D cells (producing SST), and L cells (producing GLP-1 and PYY)
FDA-approved options like Wegovy and Zepbound are regulated and reliable but cost $900$1,500+ per month without insurance
Currently US-only
Proper injection technique, site rotation, and allowing medication to reach room temperature can further minimize discomfort