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Iron overload modulates follicular microenvironment via ROS/HIF-1/FSHR signaling [J]

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This study primarily utilized in vitro models to validate the ferroptosis-inducing effects of HT, without evaluation in animal models or clinical samples

Interestingly, a recent study showed that oral supplementation of NR altered the intestinal microbial composition in rats and mice but not humans 63 , highlighting the need for further studies on this matter to assess the impact of NAD + metabolism modulation by the microbiome on health outcomes

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When empirical measures of parameter uncertainty (e.g., standard errors or confidence intervals) were not available from published sources, a conservative range of 25% was applied around the base-case value