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Structures of full-length class B receptors were determined in complex with their orthosteric agonist peptides, however, little is known about their extracellular domain (ECD) conformations in the absence of orthosteric ligands, which has limited our understanding of their activation mechanism

Venkateshappa CG, Harish RB, Mythri A, Mahadevan MM, Bharath SK, Shankar

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Here, we aimed to assess the mechanisms by which a validated peptide triagonist for GLP-1/GIP/GCG receptors (IUB447) stimulates insulin secretion in murine pancreatic islets

International Journal of Dairy Technology, 71 (4), 921933

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