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The interaction of Fas and Fas ligand (FasL) transduces an active signal for cellular apoptosis [97]

As lipid hydroperoxides are known for propagating radiation injury, understating the influence of the alteration in expression/activity level of GPx on cellular radiosensitivity has received a lot of attention among researchers

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As of June 2026, tirzepatide is FDA-approved (Zepbound, Mounjaro) and CagriSema is not

Cells also harbor multiple parallel, GPX4-independent antiferroptotic pathways, many of which rely on endogenous radical-trapping antioxidants (RTAs) that directly quench lipid radicals (Fig

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