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However, L-carnitine treatment reduced this effect and enhanced the activation of the AKT/FOXO3a/MaFbx axis

Key findings across the STEP trials: Average weight loss of ~15% of body weight roughly 15 kg (33 lbs) for a 100 kg (220 lb) person 87% of patients lost at least 5% of body weight, compared to 31% on placebo Nearly 70% of patients lost at least 10% of body weight About 1 in 3 patients lost 20% or more Weight loss was maintained throughout the treatment period with continued medication use Significant improvements in blood pressure, blood sugar, cholesterol, and inflammatory markers alongside weight loss These results are dramatically better than any prior weight loss medication

Author contributions Conceptualization: Fahad S

Alli is the brand-name version that can be found over-the-counter (OTC) and is not usually covered by insurance