Rare cases of allergic contact dermatitis have been described with prolonged copper exposure, so persistent or worsening inflammation should prompt discontinuation and medical evaluation
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Its important to note that having vitamin B12 levels too high doesnt usually cause symptoms on its own, but it can be a marker for other medical concerns that need attention
Evaluation of production: type II collagen, aggrecan, MMP-13 (degradation enzyme), IL-1 response
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